L-ornithine and L-arginine are two amino acids which are often used by bodybuilders and those in the fitness industry to improve how their bodies produce muscle. Both supplements encourage the body to produce more of the Human Growth Hormone (HGH) and will encourage the body to metabolise fat into muscle when used in conjunction with a robust exercise and weight lifting routine.
L-ornithine is mostly used because it helps the body to produce HGH which will lead to increased muscle size and strength. However it also has other benefits including wound healing, collagen production and the synthesis of protein.
People who have problems with their urea cycle will have an ornithine transcarbamylase deficiency. This is considered a genetic disorder, which people are deficient in an enzyme in their cycle. People who experience problems with their cycle will have an increased concentration of ammonia in their urine, rather than urea.
When the enzyme is missing in the bloodstream, nitrogen converts over to ammonia. When a high concentration of ammonia enters the bloodstream, it will severely damage the brain or cause the person's death. This is how the deficiency affects people. The nitrogen converts into ammonia, rather than converting into urea and properly disposed of through the kidneys and bladder.
Researchers attempting to find an effective treatment for hepatic encephalopathy incorporated L-ornithine L-aspartate (LOLA) in tests because it provides substrates for glutamine synthesis and urea formation, which rid the body of excessive ammonia.
Ornithine and aspartate convert to alpha-ketoglutarate, which is used to treat intestinal disorders, kidney disease, liver problems, stomach disorders, cataracts, and recurring yeast infections.
Ornithine and arginine are amino acids. As is the case with most amino acids, their source is primarily found in protein foods such as eggs, dairy, fish, and meat. Unlike lysine, the body manufactures ornithine, which occurs during the production of urea when arginine is metabolized.
Research studies on animals have shown that ornithine and arginine may promote the building of muscles by increasing growth and insulin hormone levels. Research on humans does not support this theory if intake is kept at reasonable levels.
When people experience high ammonia levels in their blood stream, they will need to take a medication that counteracts the making of ammonia. People often are missing an enzyme to help convert the nitrogen into urea. People will experience negative health effects if they do not control the ammonia concentration in their blood. They will often take ornithine aspartate daily to prevent ammonia production.
This medicine has recently been approved for use in the United States. People in Europe have used the medicine for years to treat high concentrations of ammonia in the body. People who take this medicine will mix one teaspoon in one glass of juice or water. This helps bodies absorb the medicine quicker than if it was in a time-released capsule.
Ornithine is an amino acid found in fish, meat, eggs, and dairy, but the body also produces it when arginine is metabolized, producing urea. The two amino acids are believed to aid muscle building in the body because they increase growth-promoting hormones.
Ornithine aspartate appears to offer some improvement in brain abnormalities caused by liver cirrhosis. Clinical testing against a placebo showed significant improvement for those taking ornithine aspartate in both blood tests and liver function.
L-Ornithine L-Aspartate Research